Does Ozempic Cause Joint Pain?

Does Ozempic Cause Joint Pain?
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Washington, DC – Quite a bit of evidence points to dangerous Ozempic side effects including stomach paralysis, pancreatitis, blindness, thyroid cancer and bowel obstruction. As of early January 2025, more than 1,300 Ozempic side-effect lawsuits were pending in consolidated proceedings.

Open questions remain about the connection between Ozempic and another side-effect — joint pain. Novo Nordisk, reports that about 1 percent of patients who participated in clinical trials for Ozempic experienced joint pain. However, this rate may not be the actual incidence because some cases of joint pain may not be reported.

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Patients have described several different types of discomfort, including stiffness, aching, and swelling. The pain may be dull or sharp and stabbing. It can also be intermittent, with periods of relief followed by flare-ups.

On the other hand, Ozempic has also been used to treat autoinflammatory diseases, such as rheumatoid arthritis. The evidence is confusing and contradictory.

The confusion about the link between Ozempic and joint pain highlights, once more, how little patients know about Ozempic side-effects, which can range in severity, even becoming life-threatening.

How Ozempic works

Originally developed to treat diabetes, Ozempic belongs to a class of medications known as GLP-1 agonists. GLP-1 is a hormone produced in the gut that plays a crucial role in regulating blood sugar levels. GLP-1s help stimulate the release of insulin, which in turn lowers blood sugar levels. But that is apparently not all that it does. The key to understanding the potential link between Ozempic and undesirable side effects like joint pain may lie in the same way that it produces beneficial effects like lowering blood sugar.

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Studies of the connection between NAIOIN blindness (nonarteritic anterior ischemic optic neuropathy) and Ozempic, for example, suggest that  an abrupt decrease in blood sugar levels may damage blood vessels that support the optic nerve.

As another example, semaglutides, like Ozempic, seem to stimulate extra production of the digestive enzymes amylase and lipase. These are both healthy substances that break down food into energy, but too much of either is considered a sign of pancreatic disorder, which can be deadly.

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None of this speaks directly to the mystery of joint pain, but these examples may offer clues. From a very non-scientific perspective, the pain does seem to have something to do with how some people metabolize the drug.

No, the pain is not all in your head

Joint pain is caused by an inflammation of the joints. It is often associated with osteoarthritis. The inflammation, though, may have many different causes. Joint pain may be associated with obesity or overweight, which may also be treated with GLP-1 drugs. It may also be the result of kidney disease or kidney failure, or the use of medications such as blood thinners, immunosuppressants or corticosteroids. It may be a symptom of autoimmune diseases such as lupus. People with existing joint diseases appear to have a greater risk of developing Ozempic-related complications.

Still, it appears that taking Ozempic may increase an individual’s chances of developing joint pain. The evidence for this causal relationship is still somewhat anecdotal, but anyone who suffers from joint pain can tell you that the pain is very real.

As with any chronic pain, joint pain caused by Ozempic can impact a patient’s quality of life significantly. This is not necessarily where an ice pack or some over-the-counter medication is sufficient.

Continuous joint pain can limit a person’s mobility and disrupt daily activities. It can lead to reduced physical fitness due to enforced inactivity and can cause emotional distress, impacting overall wellbeing. Moreover, the discomfort can disrupt sleep and result in fatigue, which can affect concentration and productivity, thereby adversely impacting social and professional life.

The first thing that patients suffering from severe or persistent joint pain should do is to take it seriously. Yes, it may have a simple solution. On the other hand, it may not. Auto-immune diseases, like lupus or rheumatoid arthritis, or acute kidney failure are nothing to trifle with. So, talk to a medical professional.

Do not hesitate to seek legal advice, either. The evidence for serious Ozempic side-effects has been accumulating for months, but there is still much to know. The preliminary evidentiary hearings for consolidated lawsuits are set to begin in May. The round of bellwether cases and settlements will follow thereafter. If the quality of your life has been affected by undisclosed Ozempic side-effects, you may be eligible to participate.

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